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Based on the Margaret Edson play, Vivian Bearing (Dame Emma Thompson) is a literal, hardnosed English professor who has been diagnosed with terminal ovarian cancer. During the story, she reflects on her reactions to the cycle the cancer takes, the treatments, and significant events in her life. The people that watch over her are Dr. Jason Posner (Jonathan M. Woodward), who only finds faith in being a doctor; Susie Monahan (Audrey McDonald), a nurse with a human side that is the only one in the hospital that cares for Vivian's condition; and Dr. Harvey Kelekian (Christopher Lloyd), the head doctor who just wants results no matter what they are.
